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Madras et al (2006) in a modern paper shown in vivo binding of modafinil to striatal DAT and thalamic Web in rhesus monkeys making use of PET imaging. The investigators when compared binding from the DAT probe [11C]CFT plus the Web probe [11C]MeNER within the absence of modafinil While using the binding of those probes in the presence of modafinil